Prof. Dr. Franz Bracher

Chair Holder

Department of Pharmacy

Pharmaceutical/Medicinal Chemistry

Office address:

Butenandtstr. 5-13, Haus C

Room C3.054

81377 Munich

+49 89 2180-77802

Postal address:

Butenandtstr. 5-13

Research Interests

Inhibitors of ergosterol and cholesterol biosynthesis as new drug candidates
Development of novel modulators of epigenetic target enzymes (kinases, sirtuins, …)
Development of novel modulators of cation channels (TPCs, TRPMLs)
Natural products chemistry (synthesis, biological activities)
High-end GC-MS analytics (method development, applications in biomedicine and ecology)

Studied pharmacy at the LMU Munich
1986 PhD in Pharmaceutical Chemistry, LMU Munich
1986-1987 Postdoctoral Researcher at the Department of Organic Chemistry, University of Geneve/Switzerland
1991 Habilitation, University of Marburg
1992-1997 C3 Professor, University of Braunschweig
Since 1997 C4 Professor for Pharmaceutical Chemistry, LMU Munich

M. Müller, S. Gerndt, Y.-K. Chao, T. Zisis, O. N. P. Nguyen, A. Gerwien, N. Urban, C. Müller, F. A. Gegenfurtner, F. Geisslinger, C. Ortler, C.-C. Chen, S. Zahler, M. Biel, M. Schaefer, C. Grimm, F. Bracher, A. M. Vollmar, K. Bartel: Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth. Cell Chem. Biol. 28, 1119-1131.e27 (2021)
C. Glas, J. C. B. Dietschreit, N. Wössner, L. Urban, E. Ghazy, W. Sippl, M. Jung, C. Ochsenfeld, F. Bracher: Identification of the subtype-selective Sirt5 inhibitor balsalazide through systematic SAR analysis and rationalization via theoretical investigations. Eur. J. Med. Chem. 206, 112676 (2020)
R. Schütz, M. Meixner, I. Antes, F. Bracher: A modular approach to the bisbenzylisoquinoline alkaloids tetrandrine and isotetrandrine. Org. Biomol. Chem. 18, 3047-3068 (2020)
C. Müller, J. Junker, F. Bracher, M. Giera: A gas chromatography – mass spectrometry based whole cell screening assay for target identification in distal cholesterol biosynthesis. Nature Protocols 14, 2546-2570 (2019)
C.-C. Chen, M. Keller, M. Heß, R. Schiffmann, N. Urban, A. Wolfgardt, M. Schaefer, F. Bracher, M. Biel, C. Wahl-Schott, C. Grimm: A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nature Communications 5: 4681, (2014)