Prof. Dr. Olivia Merkel
Chair Holder, Deputy Director Dept. Pharmacy
Department of Pharmacy
Research Interests
- Non-viral siRNA Delivery
- T Cell Targeting
- Molecular Treatments for Lung Diseases, Inflammatory Diseases and Cancer
- Smart Dosage Forms
- Machine Learning and Computer Simulation for Nanocarrier Design
Short CV
- Since 2022 Professor and Chair (W3) of Drug Delivery, LMU Munich, Germany
- 2016-2022 Professor (W2) of Drug Delivery, LMU Munich, Germany
- 2015-2016 Interim Professor of Drug Delivery, LMU Munich, Germany
- Since 2012 Associate Faculty of Oncology, Wayne State University
- 2011-2017 Tenure-Track Professor of Pharmaceutics, Wayne State University
- 2009-2011 Postdoc/Habil Cand, Philipps-Universität Marburg, Germany
- 2009-2011 Postdoc/Habil Cand, Philipps-Universität Marburg, Germany
- 2009 PhD in Pharmaceutical Technology, Philipps-Universität Marburg, Germany
- 2006 MS in Pharmaceutical Technology, Martin-Luther-Universität Halle, Germany
- 2005 Board License as Pharmacist, Philipps-Universität Marburg, Germany
Key publications
- Friederike Adams, Christoph M Zimmermann, Domizia Baldassi, Thomas M Pehl, Philipp Weingarten, Iris Kachel, Moritz Kränzlein, David C Jürgens, Peter Braubach, Ioannis Alexopoulos, Malgorzata Wygrecka, Olivia M Merkel*: Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis.
Small, 2023, e2308775. doi: 10.1002/smll.202308775. - Christoph M. Zimmermann, Leonie Deßloch, David C Jürgens, Paola Luciani, Olivia M. Merkel: Evaluation of the effects of storage conditions on spray-dried siRNA-LNPs before and after subsequent drying.
European Journal of Pharmaceutics and Biopharmaceutics, 2023, 193: 218-226 - Rima Kandil, Domizia Baldassi, Sebastian Böhlen, Joschka T Müller, David C Jürgens, Tonia Bargmann, Susann Dehmel, Yuran Xie, Aditi Mehra, Olivia M Merkel*: GATA3 knockdown in activated T cells via pulmonary siRNA delivery as novel therapy for allergic asthma.
Journal of Controlled Release, 2023, 354, 305-315. - Christoph M. Zimmermann, Domizia Baldassi, Karen Chan, Nathan B.P. Adams, Alina Neumann, Diana Porras-Gonzalez, Xin Wei, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Andreas Popp, Gerald Burgstaller, Dominik Witzigmann, Paola Luciani, Olivia M. Merkel*: Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery.
Journal of Controlled Release, 2022, 351, 137-150 - Domizia Baldassi, Shubhankar Ambike, Martin Feuerherd, Cho-Chin Cheng, David J Peeler, Daniel P Feldmann, Diana Porras-Gonzalez, Xin Wei, Lea Adriana Keller, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Andreas Popp, Gerald Burgstaller, Suzie H Pun, Thomas Michler, Olivia M. Merkel*: Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes.
Journal of Controlled Release, 2022, 345, 661-674