Mayr's Database Of Reactivity Parameters
AK Prof. Mayr

Other Michael acceptors

For reactivities of structurally related compounds go to: Electrophiles » C-Electrophiles » Acceptor-Substituted Ethylenes
Found 57 Molecules.
Molecule Solvent Reactivity Parameters Classification Reference (sort by title or year)
image of molecule

3-methylcyclohexenone		DMSOE Parameter: -29.60
*Chem. Sci. 2021, 12, 4850-4865
DOI: 10.1039/D0SC06628A
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3-methylcyclopentenone		DMSOE Parameter: -28.90
*Chem. Sci. 2021, 12, 4850-4865
DOI: 10.1039/D0SC06628A
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2-methylcyclohexenone		DMSOE Parameter: -27.50
*Chem. Sci. 2021, 12, 4850-4865
DOI: 10.1039/D0SC06628A
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(E)-1-methyl-4-(styrylsulfonyl)benzene (in DMSO)		DMSOE Parameter: -24.69
**J. Am. Chem. Soc. 2017, 139, 13318-13329
DOI: 10.1021/jacs.7b05106
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cinnamonitrile (in DMSO)		DMSOE Parameter: -24.60
*J. Am. Chem. Soc. 2017, 139, 13318-13329
DOI: 10.1021/jacs.7b05106
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ethyl cinnamate (in DMSO)		DMSOE Parameter: -24.52
**J. Am. Chem. Soc. 2017, 139, 13318-13329
DOI: 10.1021/jacs.7b05106
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ethyl (E)-but-2-enoate (in DMSO)		DMSOE Parameter: -23.59
**J. Am. Chem. Soc. 2017, 139, 13318-13329
DOI: 10.1021/jacs.7b05106
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N,N-dimethylprop-2-enamide (in DMSO)		DMSOE Parameter: -23.54
***J. Am. Chem. Soc. 2017, 139, 13318-13329
DOI: 10.1021/jacs.7b05106
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(E)-4-phenylbut-3-en-2-one (in DMSO)		DMSOE Parameter: -23.01
***J. Am. Chem. Soc. 2017, 139, 13318-13329
DOI: 10.1021/jacs.7b05106
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ethyl 2-methylprop-2-enoate (in DMSO)		DMSOE Parameter: -22.77
**J. Am. Chem. Soc. 2017, 139, 13318-13329
DOI: 10.1021/jacs.7b05106
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2-methylcyclopentenone		DMSOE Parameter: -22.10
***Chem. Sci. 2021, 12, 4850-4865
DOI: 10.1039/D0SC06628A
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cyclohexenone		DMSOE Parameter: -22.10
***Chem. Sci. 2021, 12, 4850-4865
DOI: 10.1039/D0SC06628A
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cycloheptenone		DMSOE Parameter: -22.00
***Chem. Sci. 2021, 12, 4850-4865
DOI: 10.1039/D0SC06628A
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dihydro-2H-pyran-2-one		DMSOE Parameter: -21.80
**Chem. Sci. 2021, 12, 4850-4865
DOI: 10.1039/D0SC06628A
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furan-2(5H)-one		DMSOE Parameter: -20.70
***Chem. Sci. 2021, 12, 4850-4865
DOI: 10.1039/D0SC06628A
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cyclopentenone		DMSOE Parameter: -20.60
***Chem. Sci. 2021, 12, 4850-4865
DOI: 10.1039/D0SC06628A
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tert-butyl prop-2-enoate (in DMSO)		DMSOE Parameter: -20.22
***J. Am. Chem. Soc. 2017, 139, 13318-13329
DOI: 10.1021/jacs.7b05106
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3-methylenetetrahydropyran-2-one		DMSOE Parameter: -19.50
***Chem. Sci. 2021, 12, 4850-4865
DOI: 10.1039/D0SC06628A
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diethyl maleate		DMSOE Parameter: -19.49
***Eur. J. Org. Chem. 2014, , 2956-2963
DOI: 10.1002/ejoc.201301779
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3-methylenedihydrofuranone		DMSOE Parameter: -19.40
***Chem. Sci. 2021, 12, 4850-4865
DOI: 10.1039/D0SC06628A
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(E)-1,3-diphenylprop-2-en-1-one (in DMSO)		DMSOE Parameter: -19.39
***J. Am. Chem. Soc. 2017, 139, 13318-13329
DOI: 10.1021/jacs.7b05106
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(E)-4-(4-nitrophenyl)but-3-en-2-one (in DSMO)		DMSOE Parameter: -19.36
*J. Am. Chem. Soc. 2011, 133, 8240-8251
DOI: 10.1021/ja200820m
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(E)-4-methyl-1-(4-nitrophenyl)pent-1-en-3-one (in DMSO)		DMSOE Parameter: -19.17
*J. Am. Chem. Soc. 2011, 133, 8240-8251
DOI: 10.1021/ja200820m
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(E)-4,4-dimethyl-1-(4-nitrophenyl)pent-1-en-3-one		DMSOE Parameter: -19.15
*J. Am. Chem. Soc. 2011, 133, 8240-8251
DOI: 10.1021/ja200820m
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ethyl prop-2-enoate (in DMSO)		DMSOE Parameter: -19.07
***J. Am. Chem. Soc. 2017, 139, 13318-13329
DOI: 10.1021/jacs.7b05106
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acrylonitrile (in DMSO)		DMSOE Parameter: -19.05
***J. Am. Chem. Soc. 2017, 139, 13318-13329
DOI: 10.1021/jacs.7b05106
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methyl prop-2-enoate (in DMSO)		DMSOE Parameter: -18.84
***J. Am. Chem. Soc. 2017, 139, 13318-13329
DOI: 10.1021/jacs.7b05106
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ethenylsulfonylbenzene (in DMSO)		DMSOE Parameter: -18.36
***J. Am. Chem. Soc. 2017, 139, 13318-13329
DOI: 10.1021/jacs.7b05106
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hex-3-yn-2-one		0E Parameter: -17.90
-Angew. Chem. Int. Ed. 2019, 58, 17704-17708
DOI: 10.1002/anie.201909803
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diethyl fumarate		DMSOE Parameter: -17.79
***Eur. J. Org. Chem. 2014, , 2956-2963
DOI: 10.1002/ejoc.201301779
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(E)-3-(4-cyano-phenyl)-1-phenyl-prop-2-en-1-one (in DMSO)		DMSOE Parameter: -17.64
***J. Am. Chem. Soc. 2011, 133, 8240-8251
DOI: 10.1021/ja200820m
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(E)-3-(4-nitro-phenyl)-1-phenyl-prop-2-en-1-one (in DMSO)		DMSOE Parameter: -17.33
***J. Am. Chem. Soc. 2011, 133, 8240-8251
DOI: 10.1021/ja200820m
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4-phenylbut-3-yn-2-one		0E Parameter: -16.90
-Angew. Chem. Int. Ed. 2019, 58, 17704-17708
DOI: 10.1002/anie.201909803
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but-3-en-2-one (in DMSO)		DMSOE Parameter: -16.76
***J. Am. Chem. Soc. 2017, 139, 13318-13329
DOI: 10.1021/jacs.7b05106
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2-phenylethene-1-sulfonyl fluoride		DMSOE Parameter: -16.63
***Angew. Chem. Int. Ed. 2016, 55, 12664-12667
DOI: 10.1002/anie.201601875
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butynone		0E Parameter: -16.60
-Angew. Chem. Int. Ed. 2019, 58, 17704-17708
DOI: 10.1002/anie.201909803
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fumaronitrile		DMSOE Parameter: -15.71
***Eur. J. Org. Chem. 2014, , 2956-2963
DOI: 10.1002/ejoc.201301779
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1-phenylprop-2-en-1-one (in DMSO)		DMSOE Parameter: -15.25
***J. Am. Chem. Soc. 2017, 139, 13318-13329
DOI: 10.1021/jacs.7b05106
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jul-indan-1,3-dione		0E Parameter: -14.68
***Org. Biomol. Chem. 2007, 5, 3020-3026
DOI: 10.1039/b708025e
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N-methyl maleimide		DMSOE Parameter: -14.07
***Eur. J. Org. Chem. 2014, , 2956-2963
DOI: 10.1002/ejoc.201301779
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jul Meldrum's acid		0E Parameter: -13.97
***J. Org. Chem. 2008, 73, 2738-2745
DOI: 10.1021/jo702590s
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julBBS		0E Parameter: -13.84
***J. Org. Chem. 2007, 72, 9170-9180
DOI: 10.1021/jo071273g
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2-(p-(dimethylamino)benzylidene)-indan-1,3-dione		0E Parameter: -13.56
***Org. Biomol. Chem. 2007, 5, 3020-3026
DOI: 10.1039/b708025e
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p-(dimethylamino)benzylidenemalononitrile		0E Parameter: -13.30
***J. Org. Chem. 2003, 68, 6880-6886
DOI: 10.1021/jo0344182
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dmaBBS		0E Parameter: -12.76
***J. Org. Chem. 2007, 72, 9170-9180
DOI: 10.1021/jo071273g
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p-(dimethylamino)benzylidene Meldrum's acid		0E Parameter: -12.76
***J. Org. Chem. 2008, 73, 2738-2745
DOI: 10.1021/jo702590s
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ethenesulfonyl fluoride (ESF)		DMSOE Parameter: -12.09
***Angew. Chem. Int. Ed. 2016, 55, 12664-12667
DOI: 10.1002/anie.201601875
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jul(S)BBS		0E Parameter: -11.89
***J. Org. Chem. 2007, 72, 9170-9180
DOI: 10.1021/jo071273g
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2-(p-methoxybenzylidene)-indan-1,3-dione		0E Parameter: -11.32
***Org. Biomol. Chem. 2007, 5, 3020-3026
DOI: 10.1039/b708025e
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maleic anhydride		DMSOE Parameter: -11.31
***Eur. J. Org. Chem. 2014, , 2956-2963
DOI: 10.1002/ejoc.201301779
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p-(methoxy)benzylidenemalononitrile		0E Parameter: -10.80
***J. Org. Chem. 2003, 68, 6880-6886
DOI: 10.1021/jo0344182
image of molecule

dma(S)BBS		0E Parameter: -10.73
***J. Org. Chem. 2007, 72, 9170-9180
DOI: 10.1021/jo071273g
image of molecule

aniBBS		0E Parameter: -10.37
***J. Org. Chem. 2007, 72, 9170-9180
DOI: 10.1021/jo071273g
image of molecule

p-(methoxy)benzylidene Meldrum's acid		0E Parameter: -10.28
***J. Org. Chem. 2008, 73, 2738-2745
DOI: 10.1021/jo702590s
image of molecule

2-benzylidene-indan-1,3-dione		0E Parameter: -10.11
***Org. Biomol. Chem. 2007, 5, 3020-3026
DOI: 10.1039/b708025e
image of molecule

benzylidenemalononitrile		0E Parameter: -9.42
***J. Org. Chem. 2003, 68, 6880-6886
DOI: 10.1021/jo0344182
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benzylidene-Meldrum's acid		0E Parameter: -9.15
***J. Org. Chem. 2008, 73, 2738-2745
DOI: 10.1021/jo702590s
 
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