Publications

2024

Gotz M, Barth A, Bohr SS, Borner R, Chen J, Cordes T, Erie DA, Gebhardt C, Hadzic M, Hamilton GL, Hatzakis NS, Hugel T, Kisley L, Lamb DC, de Lannoy C, Mahn C, Dunukara D, de Ridder D, Sanabria H, Schimpf J, Seidel CAM, Sigel RKO, Sletfjerding MB, Thomsen J, Vollmar L, Wanninger S, Weninger KR, Xu P, and Schmid S.
Reply to: On the statistical foundation of a recent single molecule FRET benchmark
Nat. Commun. 2024, 15:3626. [doi link]
Asadiatouei P, Salem CB, Wanninger S, Ploetz E, Lamb DC.
Deep-LASI, single-molecule data analysis software.
Biophys. J. 2024, Online [doi link]
Wang L, Chen HJ, Wang ZG, Ning D, Zhao W, Rat V, Lamb DC, Pang PW, Liu SL.
Mapping Extracellular Space Features of Viral Encephalitis to Evaluate the Proficiency of Anti-Viral Drugs.
Adv. Mater. 2024, Online [doi link]
Agam G, Barth A, Lamb DC.
Folding pathway of a discontinuous two-domain protein.
Nat. Commun. 2024, Online [doi link]

2023

Glück IM, Grusha PM, Strauss S, Rat V, Gialdini I, Ebert TS, Stafford C, Agam G, Manley S, Hornung V, Jungmann R, Sieben C, Lamb DC.
Nanoscale organization of the endogenous ASC speck
iScience 2023, 26:108382. [doi link]
Wanninger S, Asadiatouei P, Bohlen J, Salem CB, Tinnefeld P, Ploetz E, Lamb DC.
Deep-LASI: Deep-Learning Assisted, Single-molecule Imaging analysis of multi-color DNA Origami structures
Nat. Commun. 2023, 14:6564. [doi link]
Guthmann M, Qian C, Gialdini I, Nakatani T, Ettinger A, Schauer T, Kukhtevich I, Schneider R, Lamb DC, Burton A, Torres-Padilla ME.
A change in biophysical properties accompanies heterochromatin formation in mouse embryos
Genes & Dev. 2023, 37:336-350. [doi link]
Schröder T, Bohlen J, Ochman SE, Schüler P, Krause S, Lamb DC, Tinnefeld P.
Shrinking gate fluorescence correlation spectroscopy yields equilibrium constants and separates photophysics from structural dynamics
PNAS 2023, 120(4):e2211896120. [doi link]
Agam G, Gebhardt C, Popara M, Mächtel R, Folz J, Ambrose B, Chamachi N, Chung SY, Craggs TD, de Boer M, Grohmann D, Ha T, Hartmann A, Hendrix J, Hirschfeld V, Hübner CG, Hugel T, Kammerer D, Kang HS, Kapanidis AN, Krainer G, Kramm K, Lemke EA, Lerner E, Margeat E, Martens K, Michaelis J, Mitra J, Moya Muñoz GG, Quast RB, Robb NC, Sattler M, Schlierf M, Schneider J, Schröder R, Sefer A, Tan PS, Thurn J, Tinnefeld P, van Noort J, Weiss S, Wendler N, Zijlstra N, Barth A, Seidel CAM, Lamb DC, Cordes T.
Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins
Nat. Meth. 2023, 20:523-535. [doi link]
Kirst C, Knechtel F, Gensler M, Fischermeier D, Petersen J, al Danaf N, Tietze J, Wedel A, Lamb DC, Mitric R, Karaghiosoff K.
Aggregation-Induced Emission in a Flexible Phosphine Oxide and its Zn(II) Complexes - A Simple Approach to Blue Luminescent Materials
Adv. Funct. Mater. 2023, 33(13):2212436. [doi link]
Mieskes F, Ploetz E, Wehnekamp F, Virgile R, Lamb DC.
Multicolor 3D Orbital Tracking
Small 2023, 19(17):2204726. [doi link]

2022

Gotz M, Barth A, Bohr SSR, Borner R, Chen JX, Cordes T, Erie DA, Gebhardt C, Hadzic MCAS, Hamilton GL, Hatzakis NS, Hugel T, Kisley L, Lamb DC, de Lannoy C, Mahn C, Dunukara D, de Riddler D, Sanabria H, Schimpf J, Seidel CAM, Sigel RKO, Sletfjerding MB, Thomsen J, Vollmar L, Wanninger S, Weninger KR, Xu PN, Schmid S.
A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories
Nat. Comm. 2022, 13(1):5402. [doi link]
Al Danaf N, Kretzschmar J, Jahn B, Singer H, Pol A, Op den Camp HJM, Steudtner R, Lamb DC, Drobot B, Daumann LJ.
Studies of pyrroloquinoline quinone species in solution and in lanthanide-dependent methanol dehydrogenases
Phys. Chem. Chem. Phys. 2022, 24(25):15397-15405. [doi link]
Hoyer M, Crevenna AH, Kitel R, Willems K, Czub M, Dubin G, Van Dorpe P, Holak TA, Lamb DC.
Analysis tools for single-monomer measurements of self-assembly processes
Sci. Reports 2022, 12(1):4682. [doi link]
Messer P, Henß AK, Lamb DC, Wintterlin J.
A Multiscale Wavelet Algorithm for Atom Tracking in STM Movies.
New J. Phys. 2022, 24:033016. [doi link]
Biebl MM, Delhommel F, Faust O, Zak KM, Agam G, Guo X, Mühlhofer M, Dahiya V, Hillebrand D, Popowicz GM, Kampmann M, Lamb DC, Rosenzweig R, Sattler M, Buchner J.
NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems.
Mol. Cell 2022, 82(3):555–569. [doi link]
Qian C, Flemming A, Müller B, Lamb DC.
Dynamics of HIV-1 Gag Processing as Revealed by Fluorescence Lifetime Imaging Microscopy and Single Virus Tracking
Viruses 2022, 14(2):340. [doi link]
Hoyer M, Crevenna AH, Cabral Correia JR, Quezada AG, Lamb DC.
Zero-mode waveguides visualize the first steps during gelsolin-mediated actin filament formation.
Biophys. J. 2022, 121(2):327-335. [doi link]

2021

Bravo JPK, Bartnik K, Venditti L, Acker J, Gail EH, Colyer A, Davidovich C, Lamb DC, Tuma R, Calabrese AN, Borodavka A.
Structural basis of rotavirus RNA chaperone displacement and RNA annealing.
PNAS 2021, 118(41) e2100198118 [doi link]
Karg CA, Wang SJ, Al Danaf N, Pemberton RP, Bernard D, Kretschmer M, Schneider S, Zisis T, Vollmar VM, Lamb DC, Zahler S, Moser S.
Tetrapyrrolic Pigments from Heme- and Chlorophyll Breakdown are Actin-Targeting Compounds.
Angewandte 2021, 60(41): 22578-22584 [doi link]
Kirst C, Al Danaf N, Knechtel F, Arczynski T, Mayer P, Lamb DC, Karaghiosoff KL.
Methods for elucidating the structural-property relationship in luminescent materials.
J. Mater. Chem. C 2021, 9:13366-13375 [doi link]
von Voithenberg LV, Barth A, Trauschke V, Demarco B, Tyagi S, Koehler C, Lemke EA, Lamb DC.
Comparative analysis of the coordinated motion of Hsp70s from different organelles observed by single-molecule three-color FRET.
Proc. Nat. Sci. USA 2021, 118:e2025578118 [doi link]
Al Danaf N, Schrimpf W, Hirschle P, Lamb DC, Ji Z, Wuttke S.
Linker Exchange via Migration along the Backbone in Metal-Organic Frameworks.
J. Am. Chem. Soc. 2021, 143:10541-10546 [doi link]
Lerner E, Barth A, Hendrix J, Ambrose B, Birkedal V, Blanchard SC, Börner R, Chung HS, Cordes T, Craggs TD, Deniz AA, Diao J, Fei J, Gonzalez RL, Gopich IV, Ha T, Hanke CA, Haran G, Hatzakis NS, Hohng S, Hong SC, Hugel T, Ingargiola A, Joo C, Kapanidis AN, Kim HD, Laurence T, Lee NK, Lee TH, Lemke EA, Margeat E, Michaelis J, Michalet X, Myong S, Nettels D, Peulen TO, Ploetz E, Razvag Y, Robb NC, Schuler B, Soleimaninejad H, Tang C, Vafabakhsh R, Lamb DC, Seidel CAM, Weiss S.
FRET-based dynamic structural biology: challenges, perspectives and an appeal for open-science practices.
eLIFE 2021, 10:e60416 [doi link]
Savitskiy S, Wachtel R, Pourjafar-Dehkord D, Kang HS, Trauschke V, Lamb DC, Sattler M, Zacharias M, Itzen A.
Proteolysis of Rab32 by Salmonella GtgE induces an inactive GTPase Conformation.
iSciences 2021, 24(1):101940 [doi link]
Wang ZG, Wang L, Lamb DC, Chen HJ, Hu YS, Wang HP, Pang DW, Liu SL.
Real-Time Dissecting the Dynamics of Drug Transportation in the Live Brain.
Nano Letters 2021, 21(1):642-650 [doi link]

2020

Dupont A, Glück IM, Ponti D, Stirnnagel K, Hütter S, Perrotton F, Stanke N, Richter S, Lindemann D, Lamb DC.
Identification of an Intermediate Step in Foamy Virus Fusion.
Viruses 2020, 12(12):1472 [doi link]
Mulholland CB, Nishiyama A, Ryan J, Nakamura R, Yiğit M, Glück IM, Trummer C, Qin W, Bartoschek MD, Traube FR, Parsa E, Ugur E, Modic M, Acharya A, Stolz P, Ziegenhain C, Wierer M, Enard W, Carell T, Lamb DC, Takeda H, Nakanashi M, Bultmann S, Leonhardt H.
Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive demethylation in mammals.
Nat. Commun. 2020, 11:5972 [doi link]
Heckmeier PJ, Agam G, Teese MG, Hoyer M, Stehle R, Lamb DC, Langosch D.
Determining the Stoichiometry of Small Protein Oligomers using Steady State Fluorescence Anisotropy.
Biophys. J. 2020, 119:99-114 [doi link]
Coullomb A, Bidan CM, Qian C, Wehnekamp F, Oddou C, Albigès-Rizo C, Lamb DC, Dupont A.
QuanTI-FRET: a framework for quantitative FRET measurements in living cells.
Sci. Rep. 2020, 10:6504 [doi link]
Mieskes F, Wehnekamp F, Plucińska G, Thong R, Misgeld R, Lamb DC.
Trajectory data of antero- and retrograde movement of mitochondria in living zebrafish larvae.
Data in Brief 2020, 29:105280 [doi link]
Ploetz E, Zimpel A, Cauda V, Bauer D, Lamb DC, Haisch C, Zahler S, Vollmar AM, Wuttke S, Engelke H.
Metal–Organic Framework Nanoparticles Induce Pyroptosis in Cells Controlled by the Extracellular pH.
Adv Mater. 2020, 32:1907267 [doi link]
Niu Z, Prade E, Malideli E, Hille K, Jussupow A, Mideksa YG, Yan LM, Qian C, Fleisch M, Messias AC, Sarkar R, Sattler M, Lamb DC, Feige MJ, Camilloni C, Kapurniotu A, Reif B.
Structural Insight into IAPP‐Derived Amyloid Inhibitors and Their Mechanism of Action.
Angew. Chem. Int. Ed. 2020, 132:5820-5830 [doi link]
Kuhn J, Lin Y, Krhac Levacic A, Al Danaf N, Peng L, Hoehn M, Lamb DC, Wagner E, Lachelt U.
Delivery of Cas9/sgRNA Ribonucleoprotein Complexes via Hydroxystearyl Oligoamino Amides.
Bioconjug. Chem. 2020, 31:729-742 [doi link]
Liu SL, Wang ZG, Xie HY, Liu AA, Lamb DC, Pang DW.
Single-Virus Tracking: From Imaging Methodologies to Virological Applications.
Chem Rev 2020 120: 1936-1979 [doi link]
Bartnik K, Barth A, Pilo-Pais M, Crevenna AH, Liedl T, Lamb DC.
A DNA origami platform for single-pair Förster Resonance Energy Transfer investigation of DNA-DNA interactions and ligation.
J. Am. Chem. Soc. 2020, 142:815-825 [doi link]

2019

Kuhn J, Klein PM, Al Danaf N, Nordin JZ, Reinhard S, Loy DM, Höhn M, El Andaloussi S, Lamb DC, Wagner E, Aoki Y, Lehto T, Lächelt U.
Supramolecular Assembly of Aminoethylene‐Lipopeptide PMO Conjugates into RNA Splice‐Switching Nanomicelles.
Adv. Funct. Mater. 2019, 29:1906432 [doi link]
Wang S, Crevenna AH, Ugur I, Marion A, Antes I, Kazmaier U, Hoyer M, Lamb DC, Gegenfurtner F, Kliesmente Z, Ziegenhain C, Enard W, Vollmar A, Zahler S.
Actin stabilizing compounds show specific biological effects due to their binding mode.
Sci. Rep. 2019, 9:9731 [doi link]
Connolly BM, Aragones-Anglada M, Gandara-Loe J, Danaf NA, Lamb DC, Metha JP, Vulpe D, Wuttke S, Silvestre-Albero J, Moghadam PZ, Wheatley AEH, Fairen-Jimenez D.
Tuning porosity in macroscopic monolithic metal-organic frameworks for exceptional natural gas storage.
Nat. Comm. 2019, 10:2345 [doi link]
Wehnekamp F, Plucińska G, Thong R, Misgeld T, Lamb DC.
Nanoresolution real-time 3D orbital tracking for studying mitochondrial trafficking in vertebrate axons in vivo.
eLIFE 2019, 8:e46059 [doi link]
Barth A, Voith von Voithenberg L, Lamb DC.
Quantitative Single-Molecule Three-Color Förster Resonance Energy Transfer by Photon Distribution Analysis.
J. Phy. Chem. B, 2019:6901-6916 [doi link]
Dahiya V, Agam G, Lawatscheck J, Rutz DA, Lamb DC, Buchner J.
Coordinated Conformational Processing of the Tumor Suppressor Protein p53 by the Hsp70 and Hsp90 Chaperone Machineries.
Mol. Cell 2019, 74:816-830 [doi link]
Zimpel A, Al Danaf N, Steinborn B, Kuhn J, Höhn M, Bauer T, Hirschle P, Schrimpf W, Engelke H, Wagner E, Barz M, Lamb DC, Lächelt U, Wuttke S.
Coordinative Binding of Polymers to Metal–Organic Framework Nanoparticles for Control of Interactions at the Biointerface.
ACS Nano 2019, 13:3884-3895 [doi link]
Henß A-K, Sakong S, Messer P K, Wiechers J, Schuster R, Lamb DC, Groß A, Wintterlin J.
Density fluctuations as door-opener for diffusion on crowded surfaces.
Science 2019, 363:715-718 [doi link]
Heiss G, Ploetz E, Voith von Voithenberg L, Viswanathan R, Glaser S, Schluesche P, Madhira S, Meisterernst M, Auble DT, Lamb DC.
Conformational changes and catalytic inefficiency associated with Mot1-mediated TBP-DNA dissociation.
Nucl. Acids Res. 2019, 47:2793-2806 [doi link]

2018

Zarrabi N, Schluesche P, Meisterernst M, Börsch M, Lamb DC.
Analyzing the Dynamics of Single TBP-DNA-NC2 Complexes Using Hiddenv Markov Models.
Biophys. J. 2018, 115:2310-2326 2018 [doi link]
Gegenfurtner FA, Zisis T, Al Danaf N, Schrimpf W, Kliesmete Z, Ziegenhain C, Enard W, Kazmaier U, Lamb DC, Vollmar AM, Zahler S.
Transcriptional effects of actin-binding compounds: the cytoplasm sets the tone.
Cell. Mol. Life Sci. 2018, 75:4539-4555 [doi link]
Barth A, Hendrix J, Fried D, Barak Y, Bayer EA, Lamb DC.
Dynamic interactions of type I cohesin modules fine-tune the structure of the cellulosome of Clostridium thermocellum.
Proc. Natl. Acad. Sci. USA 2018, 115:E11274-E11283 [doi link]
Hellenkamp B, ..., Barth A, ..., Hendrix J, ..., Lamb DC, ..., Naredi-Rainer N, ... et al.
Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study.
Nat. Methods 2018, 15:669-676 [doi link]
Schrimpf W, Lemmens V, Ji Z, Smisdom N, Ameloot M, Lamb DC, Hendrix J.
Crosstalk-free multicolor RICS using spectral weighting.
Methods 2018, 140-141:97-111 [doi link]
Bravo JPK, Borodavka A, Barth A, Calabrese AN, Mojzes P, Cockburn JJB, Lamb DC, Tuma R.
Stability of local secondary structure determines selectivity of viral RNA chaperones.
Nucl. Acids Res. 2018, 46:7924-7937 [doi link]
Schrimpf W, Jiang J, Ji Z, Hirschle P, Lamb DC, Yaghi OM, Wuttke S.
Chemical diversity in a metal-organic framework revealed by fluorescence lifetime imaging.
Nat. Commun. 2018,9:1647 [doi link]
Schrimpf W, Barth A, Hendrix J, Lamb DC.
PAM: A Framework for Integrated Analysis of Imaging, Single-Molecule, and Ensemble Fluorescence Data.
Biophys. J. 2018, 114:1518-1528 [doi link]
Voith von Voithenberg L, Lamb DC.
Single Pair Förster Resonance Energy Transfer: A Versatile Tool To Investigate Protein Conformational Dynamics.
BioEssays 2018, 40:1700078 [doi link]
Kopperger E, List J, Madhira S, Rothfischer F, Lamb DC, Simmel CS.
A self-assembled nanoscale robotic arm controlled by electric fields.
Science 2018, 359:296-301 [doi link]
Rosam M, Krader D, Nickels C, Hochmair J, Back KC, Agam G, Barth A, Zeymer C, Hendrix J, Schneider M, Antes I, Reinstein J, Lamb DC, Buchner J.
Bap (Sil1) regulates the molecular chaperone BiP by coupling release of nucleotide and substrate.
Nat. Struct. Mol. Biol. 2018, 25:90-100 [doi link]

2017

Merk H, Messer P, Ardelt MA, Lamb DC, Zahler S, Müller R, Vollmar AM, Pachmayr J.
Inhibition of the V-ATPase by Archazolid A: A New Strategy to Inhibit EMT.
Mol. Cancer Ther. 2017, 16:2329-2339 [doi link]
Nicoli F, Barth A, Bae W, Neukirchinger F, Crevenna AH, Lamb DC, Liedl T.
Directional Photonic Wire Mediated by Homo-Förster Resonance Energy Transfer on a DNA Origami Platform.
ACS Nano 2017, 11:11264-11272 [doi link]
Borodavka A, Dykeman EC, Schrimpf W, Lamb DC.
Protein-mediated RNA folding governs sequence-specific interactions between rotavirus genome segments.
eLife 2017, 6:e27453 [doi link]
Sánchez-Rico C, Voith von Voithenberg L, Warner L, Lamb DC, Sattler M.
Effects of Fluorophore Attachment on Protein Conformation and Dynamics Studied by spFRET and NMR Spectroscopy.
Chem. Eur. J. 2017, 23:14267 [doi link]
Verdeny-Vilanova I, Wehnekamp F, Mohan N, Álvarez ÁS, Borbely JS, Otterstrom JJ, Lamb DC, Lakadamyali M.
3D motion of vesicles along microtubules helps them to circumvent obstacles in cells.
J. Cell Sci. 2017, 12:e0177139 [doi link]
Luitz MP, Barth A, Crevenna AH, Bomblies R, Lamb DC, Zacharias M.
Covalent dye attachment influences the dynamics and conformational properties of flexible peptides.
Plos One. 2017 [doi link]
Heissig P, Schrimpf W, Hadwiger P, Wagner E, Lamb DC.
Monitoring integrity and localization of modified single-stranded RNA oligonucleotides using ultrasensitive fluorescence methods.
Plos One 2017, 12:e0173401 [doi link]

2016

Voith von Voithenberg L, Sánchez-Rico C, Kang H-S, Madl T, Zanier K, Barth A, Warner LR, Sattler M, Lamb DC.
Recognition of the 3' splice site RNA by the U2AF heterodimer involves a dynamic population shift.
Proc. Natl. Acad. Sci. USA 2016, 113:E7166-E7175 [doi link]
Galilee M, Britan-Rosich E, Griner SL, Uysal S, Baumgärtel V, Lamb DC, Kossiakoff AA, Kotler M, Stroud RM, Marx A, Alian A.
The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical.
Structure 2016, 24:1936-1946 [doi link]
Hendrix J, Dekens T, Schrimpf W, Lamb DC;
Arbitrary-Region Raster Image Correlation Spectroscopy.
Biophys. J. 2016, 111:1785-1796 [doi link]
Schrimpf W, Ossato G, Hirschle P, Wuttke S, Lamb DC.
Investigation of the Co-Dependence of Morphology and Fluorescence Lifetime in a Metal-Organic Framework.
Small 2016, 12:3651-3657 [doi link]
Crevenna AH, Blank B, Maiser A, Emin D, Prescher J, Beck G, Kienzle C, Bartnik K, Habermann B, Pakdel M, Leonhardt H, Lamb DC, von Blume J.
Secretory cargo sorting by Ca²⁺-dependent Cab45 oligomerization at the trans-Golgi network.
J. Cell Biol. 2016, 213:305-314[doi link]

2015

Hendrix J, Baumgärtel V, Schrimpf W, Ivanchenko S, Digman MA, Gratton E, Kräusslich HG, Müller B, Lamb DC.
Live-cell observation of cytosolic HIV-1 assembly onset reveals RNA-interacting Gag oligomers.
J. Cell Biol. 2015, 210:629-646[doi link]
Barth A, Voith von Voithenberg L, Lamb DC.
MFD-PIE and PIE-FI: Ways to Extract More Information with TCSPC.
Advanced Photon Counting: Applications, Methods, Instrumentation. 2015 [link]
Geng Y, Kedrov A, Caumanns JJ, Crevenna AH, Lamb DC, Beckmann R, Driessen AJM.
Role of the cytosolic loop C2 and the C-terminus of YidC in ribosome binding and insertion activity.
J. Biol. Chem. 2015, 290:17250-17261 [doi link]
Crevenna AH, Arciniega M, Dupont A, Mizuno N, Kowalska K, Lange OF, Wedlich-Soeldner R, Lamb DC.
Side-Binding Proteins Modulate Actin Filament Dynamics.
eLife 2015, 4:e04599 [doi link]
Röhl A, Wengler D, Madl T, Lagleder S, Tippel F, Herrmann M, Hendrix J, Richter K, Hack G, Schmid AB, Kessler H, Lamb DC, Buchner J.
Hsp90 Regulates the Dynamics of Its Cochaperone Sti1 and the Transfer of Hsp70 Between Modules.
Nat. Commun. 2015, 6:6655 [doi link]
Prescher J, Baumgärtel V, Ivanchenko S, Torrano AA, Bräuchle C, Müller B, Lamb DC.
Super-Resolution Imaging of ESCRT-Proteins at HIV-1 Assembly Sites
PloS Pathog. 2015, 11(2):e1004677 [doi link]

2014

Ozgen H, Schrimpf W, Hendrix J, de Jonge JC, Lamb DC, Hoekstra D, Kahya N, Baron W.
The Lateral Membrane Organization and Dynamics of Myelin Proteins PLP and MBP Are Dictated by Distinct Galactolipids and the Extracellular Matrix.
PloS One 2014, 9(7):e101834 [doi link]
Möckl L, Lamb DC, Bräuchle C.
Super-Resolved Fluorescence Microscopy: Nobel Prize in Chemistry 2014 for Eric Betzig, Stefan Hell, and William E. Moerner.
Angew. Chem. Int. Ed. 2014, 53:13972-13977 [doi link]
Rahman SA, Koch P, Weichsel J, Godinez WJ, Schwarz U, Rohr K, Lamb DC, Kräusslich HG, Müller B.
Investigating the role of F-actin in human immunodeficiency virus assembly by live-cell microscopy.
J. Virol. 2014, 88:7904-7914. [doi link]
Abate C, Niso M, Marottoli R, Riganti C, Ghigo D, Ferorelli S, Ossato G, Perrone R, Lacivita E, Lamb DC.
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and s Receptors Binding Properties
J. Med. Chem. 2014, 57:3314-3323 [doi link]
Gietl A, Holzmeister P, Blombach F, Schulz S, von Voithenberg LV, Lamb DC, Werner F, Tinnefeld P, Grohmann D.
Eukaryotic and archaeal TBP and TFB/TF(II)B follow different promoter DNA bending pathways.
Nucl. Acids Res. 2014, 42:6219-6231. [doi link]
Zhang CY, Kos P, Müller K, Schrimpf W, Troiber C, Lächelt U, Scholz C, Lamb DC, Wagner E.
Native chemical ligation for conversion of sequence-defined oligomers into targeted pDNA and siRNA carriers
J. Control. Release 2014, 180:42-50 [doi link]
Hendrix J, Lamb DC
Implementation and application of pulsed interleaved excitation for dual-color FCS and RICS.
Methods Mol Biol. 2014, 1076:653-82. [doi link]
Mashaghi A, Kramer G, Lamb DC, Mayer MP, Tans SJ.
Chaperone action at the single-molecule level.
Chem. Rev. 2014, 114:660-676 [doi link]

2013

Hendrix J, Schrimpf W, Höller M, Lamb DC.
Pulsed interleaved excitation fluctuation imaging.
Biophys J. 2013, 105:848-861 [doi link]
Dupont A, Gorelashvili M, Schüller V, Wehnekamp F, Arcizet D, Katayama Y, Lamb DC*, Heinrich D*.
Three dimensional single-particle tracking in live-cells: news from the third dimension.
New J. Phys. 2013, 15:075008 [doi link]
Dupont A, Stirnnagel K, Lindemann D, Lamb DC.
Tracking image correlation: Combining single-particle tracking and image correlation.
Biophys J. 2013, 104:2373-2382 [doi link]
Sikor M, Mapa K, von Voithenberg LV, Mokranjac D, Lamb DC.
Real-time observation of the conformational dynamics of mitochondrial Hsp70 by spFRET.
EMBO J. 2013, 32:1639-1649 [doi link]
Crevenna AH, Naredi-Rainer N, Schönichen A, Dzubiella J, Barber DL, Lamb DC, Wedlich-Söldner R.
Electrostatic control of actin filament nucleation and elongation kinetics.
J. Biol. Chem. 2013, 288:12102-12113 [doi link]
Hendrix J, Lamb DC.
Pulsed Interleaved Excitation: Principles and Applications In Fluorescence Fluctuation Spectroscopy
Methods Enzymol. 2013, 518:205-243 [doi link]

2012

Stirnnagel K, Schupp D, Dupont A, Kudryavtsev V, Reh J, Müllers E, Lamb DC, Lindemann D.
Differential pH-dependent cellular uptake pathways among foamy viruses elucidated using dual-colored fluorescent particles.
Retrovirology. 2012, 9:71 [doi link]
Baumgärtel V, Müller B, Lamb DC.
Quantitative live-cell imaging of human immunodeficiency virus (HIV-1) assembly.
Viruses. 2012, 4:777-799 [doi link]
Reuel NF, Dupont A, Thouvenin O, Lamb DC, Strano MS.
Three-dimensional tracking of carbon nanotubes within living cells.
ACS Nano 2012, 6:5420-5428 [doi link]
Bein T, Lamb DC, Michaelis J.
A Man for Single Molecules.
ChemPhysChem 2012, 13:883-884 [doi link]
Crevenna AH, Naredi-Rainer N, Schulz JCF, Wedlich-Söldner R, Lamb DC, Dzubiella J.
Effects of Hofmeister Ions on the α-Helical Structure of Proteins
Biophys. J. 2012, 102:907-915 [doi link]
Foo YH, Naredi-Rainer N, Lamb DC, Ahmed S, Wohland T.
Factors Affecting the Quantification of Biomolecular Interactions by Fluorescence Cross-Correlation Spectroscopy. (2012)
Biophys. J. 2012, 102:1174-1183 [doi link]
Kudryavtsev V, Sikor M, Kalinin S, Mokranjac D, Seidel CAM, Lamb DC.
Combining MFD and PIE for Accurate Single-Pair Förster Resonance Energy Transfer Measurements.
ChemPhysChem 2012, 13:1060-1078 [doi link]

2011

Dupont A, Lamb DC.
Nanoscale Three-Dimensional Single Particle Tracking.
Nanoscale 2011, 3:4532-4541 [doi link]
Baumgärtel V, Ivanchenko S, Dupont A, Sergeev M, Wiseman PW, Kräusslich H-G, Bräuchle C, Müller B, Lamb DC.
Live-cell visualization of dynamics of HIV budding site interactions with an ESCRT component.
Nat. Cell. Biol. 2011, 13:469-474 [doi link]
Marcinowski M*, Höller M*, Feige MJ, Baerend D, Lamb DC, Buchner J.
Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions.
Nat. Struct. Mol. Biol. 2011, 18:150-158 [doi link]

2010

Chakraborty K, Chatila M, Sinha J, Shi Q, Poschner BC, Sikor M, Jiang G, Lamb DC, Hartl FU,
Hayer-Hartl M.
Chaperonin-Catalyzed Rescue of Kinetically Trapped States in Protein Folding .
Cell 2010, 142:112-122 [doi link]
Mapa K, Sikor M, Kudryavtsev V, Waegemann K, Kalinin S, Seidel CAM, Neupert W, Lamb DC, Mokranjac D.
The Conformational Dynamics of the Mitochondrial Hsp70 Chaperone.
Mol. Cell 2010, 38:89-100 [doi link]

2009

Ivanchenko S, Godinez WJ, Lampe M, Kräusslich H-G, Eils R, Rohr K, Bräuchle C, Müller B, Lamb DC.
Dynamics of HIV-1 assembly and release.
PLoS Pathog. 2009, 5(11):e1000652 [doi link]
Katayama Y, Burkacky O, Meyer M, Bräuchle C, Gratton E, Lamb DC.
Real-Time Nanomicroscopy via Three-Dimensional Single-Particle Tracking.
ChemPhysChem 2009, 10:2458-2464 [doi link]
Heiss G, Lapiene V, Kukolka F, Niemeyer CM, Bräuchle C, Lamb DC.
A Single Molecule Investigation of a Photoswitchable Nanodevice.
Small 2009, 5:1169-1175 [doi link]

2008

Bismuto E, Maggio ED, Pleus S, Sikor M, Röcker C, Nienhaus GU, Lamb DC.
Molecular Dynamics Simulation of Acidic Compact State of Apomyglobin from Yellowfin Tuna.
PROTEINS: Structure, Function, and Bioinformatics 2008, 74(2):273-290 [doi link]
Lange S, Katayama Y, Schmid M, Burkacky O, Bräuchle C, Lamb DC, Jansen RP.
Simultaneous transport of different localized mRNAs species revealed by live-cell imaging.
Traffic 2008, 9:1256-1267 [doi link]
Endreß T, Lampe M, Briggs JAG, Kräusslich H-G, Bräuchle C, Müller B, Lamb DC.
HIV-1- Cellular Interactions Analyzed by Dual-Color Single Virus Tracing.
Eur. Biophys. J. 2008, 37:1291-1301 [PDF].
Sharma S, Chakraborty K, Müller BK, Astola N, Tang Y-C, Lamb DC, Hayer-Hartl M, Hartl FU.
Monitoring Protein Conformation along the Pathway of Chaperonin-Assisted Folding.
Cell 2008, 133:142-153 [doi link]
Lamb DC, Müller BK, Bräuchle C.
Pulsed Interleaved Excitation: Eine multidimensionale Fluoreszenzmethode.
BIOSpektrum 2008, 14:166-168 [PDF]

2007

Lamb DC, Bräuchle C.
Dem Molekül auf der Spur.
Physik Journal 2007, 6:39-46 [PDF]
Schluesche P, Stelzer G, Piaia E, Lamb DC, Meisterernst M.
NC2 mobilizes TBP on core promoter TATA boxes.
Nat. Struct. Mol. Biol. 2007, 14:1196-1201 [doi link]
Lampe M, Briggs JAG, Endress T, Glass B, Riegelsberger S, Kräusslich H-G, Lamb DC, Bräuchle C, Müller B.
Double-labelled HIV-1 particles for study of virus-cell interaction.
Virology 2007, 360:92-104 [doi link]
Müller BK, Reuter A, Simmel FC, Lamb DC.
Single-pair FRET characterization of DNA tweezers.
Nano Lett. 2007, 6:2814-2820 [doi link]

2006

Kukolka F, Müller BK, Paternoster S, Niemeyer CM, Bräuchle C, Lamb DC.
A Single-Molecule Förster Resonance Energy Transfer Analysis of Fluorescent DNA-Protein Conjugates for Nanobiotechnology.
Small 2006, 2:1083-1089 [doi link]
Coban O, Lamb DC, Zaychikov E, Heumann H, Nienhaus GU.
Conformational Heterogeneity in RNA Polymerase observed by Single Pair FRET Microscopy.
Biophys. J. 2006, 90:4605-4617 [doi link]
Jung C, Müller BK, Lamb DC, Nolde F, Müllen K, Bräuchle C.
A new photostable terrylene diimide dye for applications in single molecule studies and membrane labeling.
J. Am. Chem. Soc. 2006, 128:5283-5291 [doi link]

2005

Lamb DC, Müller BK, Bräuchle C.
Enhancing the Sensitivity of Fluorescence Correlation Spectroscopy by Using Time-Correlated Single Photon Counting.
Curr. Pharm. Biotech. 2005, 6:405-414 [doi link]
Müller BK, Zaychikov E, Bräuchle C, Lamb DC.
Pulsed Interleaved Excitation.
Biophys. J. 2005, 89:3508-3522 [doi link]
Arcovito A, Lamb DC, Nienhaus GU, Hazemann JL, Benfatto M, Della Longa, S,
Light induced relaxation of photolysed carbonmonomy-myoglobin: a temperature-dependent X-ray Absorption Near Edge Structure (XANES) study.
Biophys. J. 2005, 88:2954-2964 [doi link]

2004 and before

Lamb DC, Arcovito A, Nienhaus K, Minkow O, Draghi F, Brunori M, Nienhaus GU.
Structural Dynamics of myoglobin: an infrared kinetic study of ligand migration in mutants YQR and YQRF.
Biophys. Chem. 2004, 109:41-58 [doi link]
Patel R, Kumar U, Lamb DC, Eid JS, Rocheville M, Grant M, Rani A, Hazlett T, Patel S, Gratton E, Patel Y.
Ligand binding to somatostatin receptors induces receptor-specific oligomer formation in live cells.
Proc. Natl. Acad. Sci. USA 2002, 99:3294-3299 [PDF]
Nienhaus K, Lamb DC, Deng P, Nienhaus GU.
The Effect of Ligand Dynamics on Heme Electronic Transition Band III in Myoglobin.
Biophys. J. 2002, 82:1059-1067 [doi link]
Lamb DC, Nienhaus K, Arcovito A, Draghi F, Miele AE, Brunori M, Nienhaus GU.
Structural Dynamics of Myoglobin: Ligand Migration among protein cavities studied by Fourier Transform Infrared/Temperature Derivative Spectroscopy.
J. Biol. Chem. 2002, 277:11636
Bismuto E, Gratton E, Lamb DC.
Dynamics of ANS Binding to Tuna Apomyoglobin Measured with Fluorescence Correlation Spectroscopy.
Biophys. J. 2001, 81:3510-3521 [doi link]
Lamb DC, Schenk A, Röcker C, Scalfi-Happ C, Nienhaus GU.
Sensitivity Enhancement in Fluorescence Correlation Spectroscopy of Multiple Species Using Time-Gated Detection.
Biophys. J. 2000, 79:1129-1138 [doi link]
Lamb DC, Kriegl J, Kastens K, Nienhaus GU.
Quantum-Mechanical Tunneling of Water in Heme Proteins.
J. Phys. Org. Chem. 2000, 13:659-663 [doi link]
Lamb DC, Schenk A, Röcker C, Nienhaus GU.
Determining Chemical Rate Coefficients Using Time-gated Fluorescence Correlation Spectroscopy.
J. Phys. Org. Chem. 2000, 13:654-658 [doi link]
Engler N, Ostermann A, Gassmann A, Lamb DC, Prusakov VE, Schott J, Schwitzer-Stenner, Parak FG.
Protein dynamics in an intermediate state of myogloin: Investigations by optical absorption spectroscopy, resonance Raman spectroscopy and X-ray structure analysis.
Biophys. J. 2000, 78:2081-2092 [doi link]
Prusakov VE, Lamb DC, Parak FG, Goldanskii VI.
Photoinitiated Generation of Reduced Myoglobin Intermediates at Cryogenic Temperatures and Their Relaxation.
Chem. Phys. Reports. 1999, 18:835-853.
Prusakov VE, Lemb DK (Lamb DC), Parak FG, Goldanskii VI.
Photoinitiated Generation of Reduced Intermediate States of Myoglobin at Cryogenic Temperatures and Their Relaxation.
Khim. Fiz. 1999, 18: 19-29 (in Russian).
Lamb DC, Tribble J, Doukas AG, Flotte TJ, Ossoff RH, Reinisch L.
Custom Designed Acoustical Pulses.
J. Biomed. Opt. 1999, 4: 217-223 [doi link]
Lamb DC, Prusakov V, Engler N, Ostermann A, Schellenberg P, Parak FG, Nienhaus GU.
Photodissociation and Rebinding of H2O to Ferrous Sperm Whale Myoglobin.
J. Am. Chem. Soc. 1998, 120: 2981-2982 [doi link]
Lamb DC, Ostermann A, Prusakov VE, Parak FG.
From metmyoglobin to deoxymyoglobin: Relaxations of an intermediate state.
Eur. Biophy. J. 1998, 27:113-125 [Journal page]
Tribble J, Lamb DC, Reinisch L, Edwards G.
Dynamics of gelatin ablation due to free-electron laser irradiation.
Phys. Rev. E. 1997, 55:7385-7389 [Journal page]
Lamb DC, Lin GC, Doukas AG.
Picosecond grating spectroscopy for characterizing the acoustic properties of biological material.
Appl. Optics 1997, 36:1660-1666 [doi link]
Johnson, JB, Lamb, DC, Frauenfelder, H, Müller, JD, McMahon, B, Nienhaus GU, Young RD.
Ligand Binding to Heme Proteins. VI. Interconversion of Taxonomic Substates in Carbonmonoxymyoglobin.
Biophys. J. 1996, 71:1563-1573 [PDF]
Steinbach PJ, Chu K, Frauenfelder H, Johnson JB, Lamb DC, Nienhaus GU, Sauke TB, Young RD.
Determination of rate distributions from kinetic experiments.
Biophys. J. 1992, 61:235-245 [PDF]
Young RD, Frauenfelder H, Johnson JB, Lamb DC, Nienhaus GU, Philipp R, Scholl R.
Time- and temperature dependence of large-scale conformational transitions in myoglobin.
Chem. Phys. 1991, 158:315-327 [doi link]
Steinbach PJ, Ansari A, Bendzen J, Braunstein D, Chu K, Cowen BR, Ehrenstein D, Frauenfelder H, Johnson JB, Lamb DC, Luck S, Mourant JM, Nienhaus GU, Ormos P, Philipp R, Xie A, Young RD.
Ligand binding to heme proteins: Connection between dynamics and function.
Biochemistry 1991, 30:3988-4001 [doi link]
Solomey N, Bouclier R, Charpak G, Gouz I, Lamb DC, Sauli F.
A linear drift chamber readout of a gated multistep avalanche chamber.
Nucl. Instr. Meth. 1989, A283:673-678 [doi link]
Anderson DF, Lamb DC.
Saturation effects in liquid argon doped with methane.
Nucl. Instr. Meth. 1988, A265:440-444 [doi link]
Anderson DF, Charpak G, Holroyd RA, Lamb DC.
Liquid ionization chambers with electron extraction and multiplication in the gaseous phase.
Nucl. Instr. and Meth. 1987, A261:445-448 [doi link]
Anderson DF, Lamb DC.
The importance of surface treatment on the amount of light detected from BaF2.
Nucl. Instr. and Meth. 1987, A260:377-380 [doi link]

* Asterisk indicates Corresponding author.

Conference proceedings

Schluesche P, Heiss G, Meisterernst M, Lamb DC.
Single Molecule Spectroscopy and Imaging
SPIE, San Jose, CA/USA. 2008; 68620-68628 [PDF]

Lamb DC, Doukas A, Flotte TJ, Ossoff RH, Reinisch L, Tribble J.
The free electron laser as the ideal stress-wave generator.
In Laser-Tissue Interaction VI, Jacques SL, ed. Proc. SPIE. 1995, 2391:192-201.

Charpak G, Lamb DC, Peskov V, Scigocki D, Valbis J.
New Developments in Calorimetry Based on VUV Scintillators Coupled to Photosensitive Gaseous Detectors.
ECFA Study Week on Instrumentation Technology for High-Luminosity Hadron Colliders E. Fernandez and G. Jarlskog Eds, Proceedings. 1989, 2:593-598.